Minor Recurrent Aphthous Ulcer Management with Hyaluronic Acid Gel in an Italian Cohort: A Double-Blind Randomized Clinical Trial

Background. Recurrent aphthous ulcer is a common mucosal disease and encompasses diverse interventions for its management of symptoms like pain discomfort. Since new therapies keep evolving with better outcomes as compared to traditional interventions, one such therapy using hyaluronic acid has been recently explored clinical studies based on advances in dental therapeutics. Therefore, we designed this study which double blinded randomized minor recurrent cases. Objective. To evaluate the efficacy topical oral gel treatment RAS ulcers, regard relief reduction size. Design. A double-blind controlled trial was conduct an experimental research at IRCCS Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, Milan. The participants were recruited from unit maxillofacial surgery randomly assigned test (hyaluronic gel) control groups (placebo gel). 1 : computer-generated random sequence prepared, opaque closed envelopes used allocation concealment. Participants investigators blinded. outcome measures included size (mm) visual analogue scale healing secondary measure (efficacy index). Results. mean baseline score group 1.85±1 placebo id="M2">1.85±1.2 . At day 7, id="M3">1±1.5 id="M4">2±1.5 ( id="M5">p<0.001 ). There significant group. In addition, there improvement levels id="M6">p<0.01 ) Conclusion. conclusion, decrease Hyaluronic seems have promising effects associated ulcers. Trial Registration. protocol registered Clinical Registry ISRCTN ID ISRCTN16509838, 30 June 2020. It can be accessed URL: 10.1186/ISRCTN16509838